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Across longitudinal cohorts, the menopause transition is accompanied by rises in total cholesterol, LDL, and by adverse shifts in HDL quantity and functionchanges that amplify atherogenic and hepatic inflammatory signaling 125,126,127,128,129,130

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Rodent (diet-induced obesity, 11 days) Subcutaneous 5-Amino-1MQ at roughly 34 mg/kg/day reduced body weight and white adipose mass without changing food intake or lean mass